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Title HPV infection in women with and without cervical cancer in Conakry, Guinea
Full text http://hdl.handle.net/1871/20467
Date 2009
Author(s) Keita, N.; Clifford, GM; Koulibaly, M.; Douno, K.; Kabba, I.; Haba, M.; Sylla, B.S.; Kemenade, F.J. van; Snijders, P.J.F.; Meijer, C.J.L.M.; Franceschi, S
Abstract BACKGROUND: Cervical cancer incidence in western Africa is among the highest in the world. METHODS: To investigate human papillomavirus (HPV) infection in Guinea, we obtained cervical specimens from 831 women aged 18-64 years from the general population of the capital Conakry and from 77 locally diagnosed invasive cervical cancers (ICC). Human papillomavirus was detected using a GP5 + /6 + PCR-based assay. RESULTS: Among the general population, the prevalence of cervical abnormalities was 2.6% by visual inspection and 9.5% by liquid-based cytology. Fourteen of 15 high-grade squamous intraepithelial lesions were visual inspection-negative. Human papillomavirus prevalence was 50.8% (32.1% for high-risk types) and relatively constant across all age groups. Being single or reporting >= 3 sexual partners was significantly associated with HPV positivity. HPV16 was the most common type, both among the general population (7.3%) and, notably in ICC (48.6%). HPV45 (18.6%) and HPV18 (14.3%), the next most common types in ICC, were also more common in ICC than in HPV-positive women with normal cytology from the general population. CONCLUSION: The heavy burden of HPV infection and severe cervical lesions in Guinean women calls for new effective interventions. Sixty-three per cent of cervical cancers are theoretically preventable by HPV16/18 vaccines in Guinea; perhaps more if some cross-protection exists with HPV45. British Journal of Cancer (2009) 101, 202-208. doi: 10.1038/sj.bjc.6605140 www.bjcancer.com Published online 16 June 2009 (C) 2009 Cancer Research UK Epidemiology
Type of publication Article / Letter to editor; Scholarly publ. refereed; Journal article
Source 101; British Journal of Cancer; 202; 208; 1
Identifier British Journal of Cancer, 101(1), 202-208; 00070920; 237361
Repository Amsterdam - VU University of Amsterdam
Added to C-A: 2012-05-31;22:39:58