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Title Polio immunity and the impact of mass immunization campaigns in the Democratic Republic of the Congo.
Full text https://escholarship.org/uc/item/0pt907k9
Date 2017
Author(s) Voorman, Arend; Hoff, Nicole A; Doshi, Reena H; Alfonso, Vivian; Mukadi, Patrick; Muyembe-Tamfum, Jean-Jacques; Wemakoy, Emile Okitolonda; Bwaka, Ado; Weldon, William; Gerber, Sue; Rimoin, Anne W
Abstract In order to prevent outbreaks from wild and vaccine-derived poliovirus, maintenance of population immunity in non-endemic countries is critical.We estimated population seroprevalence using dried blood spots collected from 4893 children 6-59months olds in the 2013-2014 Demographic and Health Survey in the Democratic Republic of the Congo (DRC).Population immunity was 81%, 90%, and 70% for poliovirus types 1, 2, and 3, respectively. Among 6-59-month-old children, 78% reported at least one dose of polio in routine immunization, while only 15% had three doses documented on vaccination cards. All children in the study had been eligible for at least two trivalent oral polio vaccine campaigns at the time of enrollment; additional immunization campaigns seroconverted 5.0%, 14%, and 5.5% of non-immune children per-campaign for types 1, 2, and 3, respectively, averaged over relevant campaigns for each serotype.Overall polio immunity was high at the time of the study, though pockets of low immunity cannot be ruled out. The DRC still relies on supplementary immunization campaigns, and this report stresses the importance of the quality and coverage of those campaigns over their quantity, as well as the importance of routine immunization.
Subject(s) Humans; Poliovirus; Poliomyelitis; Poliovirus Vaccine; Oral; Vaccination; Seroepidemiologic Studies; Disease Outbreaks; Child; Preschool; Infant; Democratic Republic of the Congo; Female; Male; Mass Vaccination; Immunization; Mass vaccination; Seroprevalence; Child; Preschool; Poliovirus Vaccine; Oral; Biological Sciences; Agricultural and Veterinary Sciences; Medical and Health Sciences; Virology
Coverage 5693 - 5699
Publisher eScholarship, University of California
Type of publication article
Format application/pdf
Source Vaccine, vol 35, iss 42
Rights public
Identifier qt0pt907k9
Repository Berkeley - University of California
Added to C-A: 2020-10-12;09:27:05