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Title Longitudinal assessment of associations between food insecurity, antiretroviral adherence and HIV treatment outcomes in rural Uganda.
Full text https://escholarship.org/uc/item/7m8072c9
Date 2014
Author(s) Weiser, Sheri D; Palar, Kartika; Frongillo, Edward A; Tsai, Alexander C; Kumbakumba, Elias; Depee, Saskia; Hunt, Peter W; Ragland, Kathleen; Martin, Jeffrey; Bangsberg, David R
Abstract IntroductionFood insecurity is a potentially important barrier to the success of antiretroviral therapy (ART) programs in resource-limited settings. We undertook a longitudinal study in rural Uganda to estimate the associations between food insecurity and HIV treatment outcomes.DesignLongitudinal cohort study.MethodsParticipants were from the Uganda AIDS Rural Treatment Outcomes study and were followed quarterly for blood draws and structured interviews. We measured food insecurity with the validated Household Food Insecurity Access Scale. Our primary outcomes were: ART nonadherence (adherence <90%) measured by visual analog scale; incomplete viral load suppression (>400 copies/ml); and low CD4 T-cell count (<350 cells/μl). We used generalized estimating equations to estimate the associations, adjusting for socio-demographic and clinical variables.ResultsWe followed 438 participants for a median of 33 months; 78.5% were food insecure at baseline. In adjusted analyses, food insecurity was associated with higher odds of ART nonadherence [adjusted odds ratio (AOR) 1.56, 95% confidence interval (CI) 1.10-2.20, P < 0.05], incomplete viral suppression (AOR 1.52, 95% CI 1.18-1.96, P < 0.01), and CD4 T-cell count less than 350 (AOR 1.47, 95% CI 1.24-1.74, P < 0.01). Adding adherence as a covariate to the latter two models removed the association between food insecurity and viral suppression, but not between food insecurity and CD4 T-cell count.ConclusionsFood insecurity is longitudinally associated with poor HIV outcomes in rural Uganda. Intervention research is needed to determine the extent to which improved food security is causally related to improved HIV outcomes and to identify the most effective policies and programs to improve food security and health.
Subject(s) Humans; HIV Infections; Anti-Retroviral Agents; CD4 Lymphocyte Count; Treatment Outcome; Viral Load; Cohort Studies; Longitudinal Studies; Food Supply; Adolescent; Adult; Middle Aged; Rural Population; Uganda; Female; Male; Interviews as Topic; Medication Adherence; Young Adult; AIDS; antiretroviral adherence; food insecurity; HIV; treatment outcomes; HIV/AIDS; Behavioral and Social Science; Prevention; Clinical Research; Infectious Diseases; Infection; Zero Hunger; Biological Sciences; Medical and Health Sciences; Psychology and Cognitive Sciences; Virology
Coverage 115 - 120
Publisher eScholarship, University of California
Type of publication article
Source AIDS (London, England), vol 28, iss 1
Rights public
Identifier qt7m8072c9
Repository Berkeley - University of California
Added to C-A: 2022-10-05;10:21:49